Alkali⁃Surfactant⁃Polymer (ASP) flooding can improve the flooding efficiency for oilfields which are in high water⁃cut period. In different ASP flooding stages, the rheological property of production fluid changes, which could affect the pump efficiency. Based on the improved sucker rod pumping system efficiency model, the pump depth, stroke length, stroke speed and pump diameter have been optimized through iterative algorithm. The effect of centralizer numbers, stroke length, stroke speed and flooding stages on sucker rod pumping system efficiency has been studied. The results indicate that the influence of stroke length and stroke speed is significant. The sucker rod pumping system efficiency first increased obviously and then trends to be gentle with the stroke length and speed increasing. The pumping system efficiency in main slug of ASP flooding is lowest. The centralizers can decrease the sucker rod pumping system efficiency slightly.